Retinoic Acid Receptor (RAR)-α Is Not Critically Required for Mediating Retinoic Acid Effects in the Developing Mouse Retina

Abstract

Although RARalpha mediates RARE reporter transgene activity in the neural retina, its function is not necessary for the retina to develop and function normally. These data suggest that retinoic acid regulates neural retinal development through other, possibly RAR-independent, pathways.