The Journal of Clinical Pharmacology · 1980 · 45 citations · 15 references
MedicinePharmacokineticsPharmacologyClinical PharmacologyGeneral PharmacologyPharmacokinetic ModelingCompartmental Pharmacokinetic ModelsDrug DispositionDrug DistributionDrug Half-lifePharmacokinetic ParametersPharmacokinetics Of Analgesics
A single intravenous dose of fentanyl (either 2 or 4 micrograms/kg body weight) was given to 13 healthy, young volunteer subjects. Serum fentanyl concentration decreased in a triexponential pattern. The terminal half-times were 750 and 853 minutes, respectively. A three-compartment, open, mammillary model is proposed for fentanyl kinetics.
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A physiological approach to hepatic drug clearance
G. Wilkinson, David G. Shand · Clinical Pharmacology & Therapeutics · 1975 · 1.9K citations