Publication | Closed Access
Diversity Oriented Synthesis of Pyran Based Polyfunctional Stereogenic Macrocyles and Their Conformational Studies
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Citations
32
References
2012
Year
Combinatorial ChemistryBioorganic ChemistryGlycobiologyMolecular BiologyOrganic ChemistryHeterocycle ChemistryMedicinal ChemistryDiversity Oriented SynthesisStereoselective SynthesisGlycosylationBiochemistryDiversity-oriented SynthesisBioconjugationSimple SugarPharmacologyMacrocyclic GlycoconjugatesHeterocyclicNatural SciencesPolyfunctional Stereogenic MacrocylesTheir Conformational StudiesMedicineCarbohydrate-protein InteractionDrug DiscoveryHomologous Series
A new approach to synthesize a homologous series of 14-, 15-, and 16-membered drug-like, macrocyclic glycoconjugates involving TBAHS promoted azide-propenone intramolecular cycloaddition in designed C-glycopyranosyl butenones from a simple sugar d-glucose and d-mannose is reported.
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