Gentamicin Treatment of Staphylococcal Infections

Abstract

<i>Sixteen infections caused</i>by Staphylococcus aureus<i>and six infections caused by</i>S albus<i>were treated with gentamicin sulfate. The antibiotic was effective in eradicating the</i>S<i>aureus infections in all but two patients. All six infections due to</i>S albus<i>were cured. No significant toxic effects were detected and superinfection developed in only one patient. The clinical efficacy of gentamicin correlated with its in vitro activity as determined by tube-dilution and disk-diffusion assays. All isolates of</i>S aureus<i>were inhibited by 3.1μg/ml or less of gentamicin; all isolates of</i>S albus<i>were inhibited by 0.78μg/ml or less of gentamicin. The bactericidal concentrations of gentamicin were never greater than twice the inhibitory concentrations</i>.