The Journal of Clinical Psychiatry · 1999 · 136 citations · 0 references
PharmacyPharmacotherapyPsychiatryPsychiatric PharmacotherapyPsychiatric PharmacyPsychopharmacologyBipolar Disorder PharmacotherapyMedication Therapy ManagementSchizophrenia PharmacotherapyTreatment Of Mental DisordersBipolar Spectrum DisordersDaily DosingNegative Mood SymptomsNegative Symptoms AssessmentPsychopharmacologic AlgorithmsTreatment Response Criteria
The Texas Medication Algorithm Project created detailed guidelines for managing schizophrenia, bipolar disorder, and major depressive disorder. This article outlines the algorithms devised for treating schizophrenia and related disorders. The guidelines prescribe medication sequences, dosing, duration, switch‑over tactics, and response criteria for both positive and negative symptoms at each stage. The article presents the rationale and supporting evidence for each component of the algorithms.
Article AbstractBackground: In the Texas Medication Algorithm Project (TMAP), detailed guidelines for medication management of schizophrenia and related disorders, bipolar disorders, and major depressive disorders have been developed and implemented. Discussion: This article describes the algorithms developed for medication treatment of schizophrenia and related disorders. The guidelines recommend a sequence of medications and discuss dosing, duration, and switch-over tactics. They also specify response criteria at each stage of the algorithm for both positive and negative symptoms. The rationale and evidence for each aspect of the algorithms are presented.