Increased Interleukin-8 (II-8) in Rectal Dialysate From Patients With Ulcerative Colitis: Evidence for A Biological Role for IL-8 in Inflammation of The Colon

Abstract

The colonic milieu, sampled by rectal dialysis, from patients with active UC can both activate and prime neutrophils in vitro. High concentrations of IL-8 in the colonic lumen of UC patients are partially responsible for the activating effects of rectal dialysates, and account for all of its priming effects. These findings provide direct evidence for a role for IL-8 in inflammatory bowel disease.