Mutations of E3 Ubiquitin Ligase <i>Cbl</i> Family Members Constitute a Novel Common Pathogenic Lesion in Myeloid Malignancies

Abstract

Mutations in the Cbl family RING finger domain or linker sequence constitute important pathogenic lesions associated with not only preleukemic CMML, JMML, and other MPN, but also progression to AML, suggesting that impairment of degradation of activated tyrosine kinases constitutes an important cancer mechanism.