Journal of Heterocyclic Chemistry · 1981 · 49 citations · 14 references
PharmacyMedicinal ChemistryPharmacologyCancer PharmacologyNucleic Acid ChemistrySynthetic Medicinal ChemistryNucleic Acid ModificationNucleic Acid SynthesisNucleobase ChemistryRibonucleic Acid (Rna) ChemistryNucleoside Analog SynthesisNucleoside AnalogsNucleotide AnalogsPurine AnalogsPurine ChemistryPyrimidine AnalogsPyrimidine AnaloguesPyrimidine Chemistry
Abstract The carbocyclic analogs of thymidine (IXf), 1‐β‐ribofuranosylthymine (IXg), and 1‐β‐3′‐deoxyribofuranosyl‐thymine (IXe) were synthesized by incorporating modifications into the Shaw method of synthesizing 2,4‐(1 H ,3 H )pyrimidinediones via acryloylureas. Simpler analogs of thymine nucleosides were also prepared by this method. The carbocyclic analog of thymidine displayed modest activity against Leukemia L1210 in vivo. It differs from a compound prepared previously by a Prins reaction.
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