Microsomal Prostaglandin E ₂ Synthase-1 Deletion Leads to Adverse Left Ventricular Remodeling After Myocardial Infarction

Abstract

In Ptges(+/+) mice, mPGES-1 in inflammatory cells catalyzes PGE(2) biosynthesis in the LV after MI. Deletion of mPGES-1 leads to eccentric cardiac myocyte hypertrophy, LV dilation, and impaired LV contractile function after acute MI.