Publication | Closed Access
Dehydropeptides related to β-lactam antibiotics: a scheme for the biosynthesis of Penicillins and Cephalosporins
16
Citations
0
References
1973
Year
Bioorganic ChemistryCysteinyldehydrovaline DerivativesAntimicrobial ChemotherapyAntibiotic ResistancePharmaceutical ChemistryChemical DerivativeDrug ResistanceMedicinal ChemistryBiosynthesisPeptide DerivativesAntimicrobial ResistanceAntimicrobial Drug DiscoveryBiochemistryAntibacterial AgentAntimicrobial CompoundNatural Product SynthesisPharmacologyβ-Lactam AntibioticsAntibioticsNatural SciencesMicrobiologyMedicineDerivative (Chemistry)Synthetic Chemistry
Cystinylvaline and cysteinyldehydrovaline derivatives have been oxidised to isothiazolidinones, a new group of peptide derivatives; a chemically reasonable scheme for the biosynthesis of β-lactam antibiotics is presented.