Journal of Pharmacy and Pharmacology · 1987 · 13 citations · 0 references
PharmacyPharmaceuticsPharmacologyBioavailabilityDrug DeliveryPharmacokinetic ModelingDrug DistributionDrug PermeationNitroglycerinPharmacokinetic-perfusion RelationshipsPharmacokinetics Of Cardiovascular DrugsPolyethylene
The sorption of nitroglycerin, from 5% glucose solution, by infusion sets was investigated under simulated perfusion conditions. Several burettes, sets and catheters were evaluated. The stability of the drug in the presence of glucose was also determined. High density polyethylene and glass proved satisfactory for its perfusion in solutions. A method for the evaluation of its uptake under simulated perfusion conditions is described.