Toxicity Studies on 1,1,2,2-Tetrachloro-1,2-Difluoroethane and 1,1,1,2-Tetrachloro-2,2-Difluoroethane

Abstract

Abstract The symmetric and asymmetric isomers of tetrachlorodifluoroethane produced similar effects and low order of acute toxicity in oral, inhalation, or skin tests. The symmetric isomer was mildly irritating to rabbit eyes and guinea pig skin. It was not a sensitizer for guinea pig skin. Repeated four-hour exposures of rats to 3000 ppm for 10 days disclosed slight effects on weight and nervous functions, but no significant pathologic change. Thirty 6-hour exposures (rats, mice, guinea pigs, and rabbits) to 1000 ppm produced no toxic signs. Rat hematology revealed slight leucopenia. Slight liver changes were observed histologically in rats. Atmospheric levels of either isomer should not exceed 500 ppm for hygienic purposes.