British Journal of Pharmacology · 1975 · 82 citations · 1 references
MedicineNeurosciencePharmacologyNeurochemistryNeuropharmacologyPharmacodynamicsAmino Acid NeurochemistryCholinergic PharmacologyGabaergic NeurochemistryGabaergic PharmacologyGabaergic SignalingVeterinary NeuropharmacologyGaba AgonistsGaba AntagonistsGaba Receptor AntagonismInhibitory NeurotransmissionInhibitory TransmissionMuscle Relaxant EffectsVascular Smooth Muscle PharmacologyVascular Smooth Muscle Relaxation
Gamma-aminobutyric acid (GABA) had a relaxant effect on dog cerebral arteries which was blocked only by picrotoxin, a known antagonist of GABA receptors. Other agents, adrenoceptor and ganglion blocking agents, atropine, reserpine, tetrodotoxin and ouabain, had no effect on the inhibitory action suggesting the existence of GABA receptors in the vascular smooth muscle of dog cerebral arteries.
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