Inhibition of HPV-16 E7 oncogenic activity by HPV-16 E2

E7 protein of human papilloma virus-16 induces degradation of retinoblastoma protein through the ubiquitin-proteasome pathway.

S N Boyer, David E. Wazer, Vimla Band · PubMed · 1996 · 931 citations

Life Sciences, Cell Biology, Molecular Biology +17

Inhibition of CDK activity and PCNA-dependent DNA replication by p21 is blocked by interaction with the HPV-16 E7 oncoprotein

Jens Oliver Funk, S Waga, Jo Beth Harry et al. · Genes & Development · 1997 · 515 citations · Full text

Life Sciences, Genetics, Molecular Biology +16

The human papillomavirus type 16 E6 and E7 oncoproteins cooperate to induce mitotic defects and genomic instability by uncoupling centrosome duplication from the cell division cycle

Stefan Duensing, Lily Y. Lee, Anette Duensing et al. · Proceedings of the National Academy of Sciences · 2000 · 493 citations

Life Sciences, Genetics, Oncology +17

Efficiency of binding the retinoblastoma protein correlates with the transforming capacity of the E7 oncoproteins of the human papillomaviruses.

D V Heck, Carole Yee, Peter M. Howley et al. · Proceedings of the National Academy of Sciences · 1992 · 331 citations

Life Sciences, Molecular Biology, Oncology +17

In vitro and in vivo growth suppression of human papillomavirus 16-positive cervical cancer cells by e6 siRNA

Mitsuo Yoshinouchi, Taketo Yamada, Masahiro Kizaki et al. · Molecular Therapy · 2003 · 188 citations · Full text

Life Sciences, Molecular Biology, Oncology +17