THE GROWTH OF ADULT HUMAN SKIN IN VITRO

Abstract

Summary.— In this report we investigate the role of serum in organ culture of adult human skin. The migratory overgrowth of dermis by epidermal cells is shown to depend on the presence of high molecular weight (mol. wt.) components of serum. Regeneration of the epidermis after 19 days' incubation occurs in the presence of 10% whole serum in the growth medium. DNA synthesis is found to increase in long‐term incubations in medium including serum components but not in the presence of Minimal Essential Medium (MEM) only.