<i>Aryl hydrocarbon receptor interacting protein</i> (<i>AIP</i>) gene mutation analysis in children and adolescents with sporadic pituitary adenomas

Abstract

While mutations were absent in non-GH-secreting adenoma patients, germline AIP mutations can be found in children and adolescents with GH-secreting tumours, even in the absence of family history. The present study reports the AIP mutation analysis results on patients of a single ethnic origin. Clearly, further studies are needed to improve our knowledge on the role of AIP in paediatric pituitary adenomas.