Radiation of the Rat Brain Suppresses Seizure‐Induced Neurogenesis and Transiently Enhances Excitability during Kindling Acquisition

Abstract

Our results demonstrate that brain radiation with a relatively low dose effectively suppressed the generation of new granule cells and transiently enhanced excitability during kindling acquisition. Although seizure-induced neurogenesis was lower in the radiated rats we could not detect a strong effect on the final establishment of the permanent fully kindled state, which argues against a prominent role of seizure-induced neurogenesis in epileptogenesis.