Publication | Open Access

Binding mode characterization of 6α- and 6β-N-heterocyclic substituted naltrexamine derivatives via docking in opioid receptor crystal structures and site-directed mutagenesis studies: Application of the ‘message–address’ concept in development of mu opioid receptor selective antagonists

Molecular PharmacologyDrug TargetBiochemistryMode CharacterizationMedicineRational Drug DesignMechanism Of ActionReceptor (Biochemistry)NeuropharmacologyPharmacotherapySite-directed Mutagenesis StudiesPharmacologyMolecular ModelingDrug Discovery