British Journal of Pharmacology · 1970 · 22 citations · 18 references
Life SciencesEndocrinologyPhysiologyCircadian RhythmsNeuroendocrinologyStress PhysiologyAdrenal Axis RegulationAdrenal HormonesAdrenal Steroid HormonesHypothalamic-pituitary RegulationPituitary Gland FunctionPituitary HormonesAdrenal Cortex FunctionCircadian Endocrine ControlCircadian Hormonal RegulationCircadian Regulation Of CortisolCircadian Regulation Of Pituitary HormonesCircadian Regulation Of Steroid SecretionCircadian Rhythms Of Adrenal HormonesCorticosteroid Physiology
1. Both the circadian and stress-induced changes in plasma corticosterone concentration were abolished by the inclusion of betamethasone in the drinking water of rats.2. Adrenal sensitivity to exogenous corticotrophin (ACTH) was unimpaired by the betamethasone treatment.3. The normal circadian rhythm in plasma corticosterone returned within 1 day of withdrawal of the steroid, but the response to stress was normal only after 3 days.4. The possible significance of these observations is discussed.
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