A STUDY ON THE ROLE OF CHOLINERGIC AND GAMMA AMINO BUTYRIC ACID SYSTEMS IN THE ANTI‐NOCICEPTIVE EFFECT OF GOSSYPIN

Abstract

1. The participation of cholinergic and gamma amino butyric acid (GABA) neurotransmitter systems in the anti-nociceptive effect of gossypin was investigated using pharmacological tools. 2. Physostigmine potentiated its anti-nociceptive response while atropine failed to modify it significantly. 3. THIP (4,5,6,7-tetra hydroisoxazolo (5,4-C) pyridin-3-ol) and gossypin treatment produced an additive response while bicuculline attenuated the anti-nociceptive response of gossypin. Similar observations were recorded for morphine. 4. It is suggested that cholinergic and GABAergic systems play a role in gossypin-induced anti-nociception.