Prenatal Glucocorticoid Therapy Reverses Pulmonary Immaturity in Congenital Diaphragmatic Hernia in Fetal Sheep

Abstract

Prenatal glucocorticoids correct the pulmonary immaturity of fetal sheep with CDH by physiologic, biochemical, and histologic criteria. These data, combined with previous small animal studies, have prompted the authors to initiate a prospective phase I/II clinical trial to examine the efficacy of prenatal glucocorticoids to improve the maturation of hypoplastic lungs associated with CDH.