Headache The Journal of Head and Face Pain · 1996 · 22 citations · 0 references
Life SciencesGeneticsNeurologyHuman GeneticsMedical GeneticsNeurogeneticsFamily-based Genetic AnalysisHeritabilityInheritance PatternsFamily-based HeritabilityGenetic Transmission ModelsGenetic Transmission PatternsMajor Gene EffectsMigraine AuraMigraine With AuraMigraine Without AuraMultifactorial Inheritance Models
A genetic study was performed in a group of 60 migraine patients and their first-degree relatives as well as in a group of sex- and age-matched controls. Segregation analysis showed that multifactorial inheritance seems to be the most probable mode of genetic transmission. Heritabilities were estimated according to the sex of probands and relatives. Our findings favor multifactorial inheritance, but the contribution of a major gene can not be excluded.