British Journal of Haematology · 1997 · 11 citations · 2 references
HistocompatibilityImmunodeficienciesGeneticsImmunologyGenetic EpidemiologyPathologyPost‐transplant LymphomaInterferon AlphaDisease Gene IdentificationImmunotherapyImmune-related Gene PolymorphismIfna GenesHematologyCell TransplantationLymphoid NeoplasiaTransplantationAutoimmune DiseaseAutoimmunityGene ExpressionInborn Error Of ImmunityOrgan TransplantAdult T-cell Leukemia-lymphomaMedicineGene Deletion Data
Post-transplant lymphoproliferative disorder (PTLD) is a well-recognized complication of organ transplant and has been associated with high mortality using conventional chemotherapy. We have investigated 11 cases of PTLD for alterations to the interferon alpha (IFNA) and p16 genes on chromosome 9p using archival material. 4/9 (44%) cases had deletions of the IFNA genes, in contrast to 1/59 (1.7%) cases of intermediate/high-grade de novo NHL drawn from the same geographical region. PTLD may therefore represent a distinct NHL subgroup exhibiting distinct gene pathology.
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A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types
Alexander Kamb, Nelleke A. Gruis, Jane Weaver-Feldhaus et al. · Science · 1994 · 2.8K citations
Structural relationship of human interferon alpha genes and pseudogenes
Karsten Henco, J. Brosius, A. Fujisawa et al. · Journal of Molecular Biology · 1985 · 197 citations