Hemoglobin, glucose‐6‐phosphate dehydrogenase, phosphogluconate dehydrogenase and adenylate kinase polymorphism in Moslems in Iran

Abstract

Abstract Starch‐gel electrophoresis of blood samples from 322 Moslems in Shiraz, Iran was performed for hemoglobins, glucose‐6‐phosphate dehydrogenase, phosphogluconate dehyrogenase, and adenylate kinase. Rh blood types were also studied in a similar population. The only abnormal hemoglobin found was hemoglobin D; the estimated allele frequency for D was 0.006. The glucose‐6‐phosphate dehydrogenase electrophoretic pattern of erythrocytes was predominnately the B phenotype in unaffected Moslems; a similar phenotype was found in leukocyte extracts of two G6PD deficient males. The A glucose‐6‐phosphate dehydrogenase band was found in low frequency in this non‐African population. Allele frequency estimates of phosphogluconate dehydrogenase B and of adenylate kinase 2 were comparable to those found in Europeans and in their descendents and were unlike those of aboriginal African populations. The Rh allele frequencies were: R 1 , 0.508; R 2 , 0.161; R 0 , 0.055; and r , 0.264.