Differences in Bile Acid Excretion

Abstract

Total daily bile acid excretion was measured in 10 patients with primary hypercholesteremia and in nine patients with combined hypercholesteremia and hypertriglyceridemia by using 14 C-labeled cholic acid and 3 H-labeled chenodeoxycholic acid. The average bile acid excretion by the patients with primary hypercholesteremia was 282 mg/day; that by the patients with combined hypercholesteremia and hypertriglyceridemia, 1,094 mg/day. These findings suggest a fundamental difference in cholesterol metabolism in these two types of hyperlipidemia.