Impaired Bacteriologic Response to Oral Cephalosporins in Acute Otitis Media Caused by Pneumococci with Intermediate Resistance to Penicillin

Abstract

Intermediately penicillin-resistant S. pneumoniae is associated with an impaired bacteriologic and clinical response of acute otitis media to cefaclor and cefuroxime axetil. This effect was more pronounced with cefaclor than with cefuroxime axetil.