An Enantioselective Total Synthesis of (+)‐Peloruside A

Abstract

Short and sweet: Chiral epoxides, prepared using (salen)cobalt-catalyzed ring-opening reactions, and a chromium catalyst controlled hetero-Diels–Alder reaction were used to set most of the stereocenters in the total synthesis of the microtubule-stabilizing agent peloruside A. The overall highly convergent route required only 20 steps in the longest linear sequence. MOM=methoxymethyl, TBS=tert-butyldimethylsilyl.