Concepedia

Highly Effective Catalytic Asymmetric Hydrogenations of α-Keto Esters and an α-Keto Acetal with New Neutral Chiral Pyrrolidinebisphosphine-Rhodium Complexes

Hisashi Takahashi, Toshiaki Morimoto, Kazuo Achiwa

Chemistry Letters · 1987 · 54 citations · 2 references

DOI

Concepts

Abstract

Abstract Synthesis of new chiral pyrrolidinebisphosphine–rhodium complexes and their application to the asymmetric hydrogenations of α-keto esters and an α-keto acetal are described. Among them, MCCPM-Rh gave the highest optical yield (87%) of the α-hydroxy ester and MCPM-Rh gave the 75% optical yield of the α-hydroxy acetal at the substrate to catalyst ratio (1000:1).

References

2

Preparation of new chiral pyrrolidinebisphosphines as highly effective ligands for catalytic asymmetric synthesis of R-(−)-pantolactone

Hisashi Takahashi, Masaaki Hattori, Mitsuo Chiba et al. · Tetrahedron Letters · 1986 · 71 citations

, , +15

Synthesis of inhibitors of adenosine deaminase. A total synthesis of erythro-3-(adenin-9-yl)-2-nonanol and its isomers from chiral precursors

David C. Baker, Lynn D. Hawkins · The Journal of Organic Chemistry · 1982 · 29 citations

, , +8