Synthesis, characterization, and antimicrobial activities of clubbed [1,2,4]‐oxadiazoles with fluorobenzimidazoles

Abstract

Abstract magnified image In this study, a novel series of substituted 4,6‐difluoro‐2‐{2‐[3‐(substituted‐phenyl)‐[1,2,4]‐oxadiazol‐5‐yl]‐ethyl}‐1 H ‐benzo[d]imidazole derivatives were synthesized by condensation of 2,4‐difluoro 6‐nitrophenyl amine with 3‐(substitutedphenyl‐[1,2,4]‐oxadiazol‐5yl) propionic acid by using 2,4,6‐trichlorobenzoyl chloride in the presence of triethyl amine base. The compounds were evaluated for their preliminary in vitro antibacterial activity against Pseudomonas aeruginosa , Escherichia coli , Staphylococcus aureus , and Salmonella typhosa . The antibacterial data of the tested compounds indicated that most of the synthesized compounds showed moderate activity with reference standard Gentamycin. J. Heterocyclic Chem., (2009).