The natural history and clinical significance of intermittent viraemia in patients with initial viral suppression to < 400 copies/ml

Abstract

Patients with IV > 400 copies/ml are three times more likely to experience sustained viral rebound and to have an impaired CD4 cell rise relative to those who maintain undetectable VL. This supports the adoption of a more pro-active approach to treatment intensification and the need for caution with structured treatment interruptions.