Increased Role of Peripheral Vision in Self-Induced Motion in Patients with Age-Related Macular Degeneration

Abstract

PURPOSE: The contribution of peripheral vision in inducing self-motion (vection) was investigated in people with bilateral age-related macular degeneration (AMD). METHODS: Eleven patients with bilateral AMD and dense central scotomas with no islands of functional central retina and 12 age-matched control subjects were exposed to random-dot patterns projected on a large screen. The dots either moved from left to right, inducing linear vection, or rotated about the roll axis, inducing roll vection. Latency, total vection time, and objective and subjective measures of tilt were recorded. RESULTS: The patients with AMD experienced shorter latencies than did the age-matched control participants, but the total vection time in both conditions and tilt during roll vection were the same in both groups. There was a positive correlation between objective tilt and subjective measures of tilt in the AMD, but not in the age-matched control group. There was a negative relationship between absolute scotoma size and latency. CONCLUSIONS: Two main conclusions were drawn. First, the role of peripheral vision in inducing vection is enhanced in people with bilateral central vision loss. Second, people with bilateral AMD adapt successfully to a moving environment (they do not experience vection longer, nor do they tilt more) and are more aware of their postural position than are age-matched control subjects.