Organic Letters · 2007 · 147 citations · 8 references
Natural SciencesChemistryCatalysisOrganic ChemistryOrganometallic ChemistryCatalyst DesignCatalyst PreparationCatalyst SynthesisCatalytic MaterialsMetal CatalysisOrganic SynthesisAlkylation ReactionsCatalyst ActivityCatalyst Structure - Activity RelationshipsCatalyst Structure-activity RelationshipsCopper-catalyzed CouplingTransition Metal-catalyzed SynthesisTransition-metal-catalyzed Functionalization
A general method for direct alkynylation of trifluoromethyl ketones was developed by using CuO(t)Bu-xantphos or phenanthroline complexes as catalysts. The ligands significantly enhanced the catalyst activity. In addition, KOTf, generated in the catalyst preparation step, exhibited some acceleration effects. A preliminary extension to a catalytic enantioselective CF3-substituted tertiary propargyl alcohol synthesis (up to 52% ee) is also described.
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