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Modulation of Calcium Channels in Cultured Cardiac Cells by Isoproterenol and 8-Bromo-cAMP
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1983
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Cardiac MuscleHeart FailureCalcium ChannelsNeurotransmissionCellular NeurobiologyCellular PhysiologyCa++ ConductanceSocial SciencesCultured Cardiac CellsCardiologyCell PhysiologyCardiomyopathyMolecular PhysiologyIon ChannelsNervous SystemPharmacologyCell BiologySignal TransductionNeurophysiologyCellular NeurosciencePhysiologyNerve ExcitationElectrophysiologyCardiovascular PhysiologyCentral Nervous SystemNeuroscienceMedicineNa+ Conductance
The central role played by Ca++ in the regulation of many cellular functions is widely appreciated, and the field centering around this problem is continuously growing. An important aspect of cell regulation by Ca++ is the fact that the free intracellular Ca++ concentration ([Ca++]i) can fluctuate over several orders of magnitude. In many cells, particularly in muscle and neurons, an increase in [Ca++]i is triggered by depolarization of the cell membrane. It has long been recognized that the Ca++ conductance (gCa) of these cells is greatly increased during excitation (for reviews, see Reuter 1973; Hagiwara and Byerly 1981; Tsien 1983) and that this contributes to the increase in [Ca++]i. The rise in gCa during an action potential has commonly been described by the formalism suggested by Hodgkin and Huxley (1952) for the change in Na+ conductance (gNa) during nerve excitation. However, recent detailed analyses of gCa, and particularly of the...