NewN1-Hetarylmethylene-Substituted Amidrazones with Potential Antimycobacterial Activity

Abstract

N1-Hetarylmethylene (e.g. pyridyl, 2-benzoxazolyl, 2-benzofuryl) substituted picolinic acid amidrazones and pyrazine-2-carbox-amidrazones were investigated. The compounds were accessible by reaction of the unsubstituted amidrazones with aldehydes. Pyrazine-2-carbox-N1-(2-benzoxazolylmethylene)amidrazones were obtained by a new multistep reaction. The investigated amidrazones were tested for their antibacterial activity against four strains of mycobacteria (M. tuberculosis, M. avium, M. intracellulare, M. lufu) and were shown to have rather low activity.