Zinc-induced dimerization of the amyloid-β metal-binding domain 1–16 is mediated by residues 11–14

Abstract

Abstract Analysis of complex formation between amyloid-β fragments using surface plasmon resonance biosensing and electrospray mass spectrometry reveals that region 11–14 mediates zinc-induced dimerization of amyloid-β and may serve as a potential drug target for preventing development and progression of Alzheimer's disease.