JAMA · 1975 · 11 citations · 0 references
PharmacyInfectious DiseasesPharmacologyAntimicrobial PharmacologyAntimicrobial PharmacotherapyInfectious Disease PharmacotherapyAntibacterial TherapyAntimicrobial ProphylaxisAntimicrobial TherapyCombination Antimicrobial TherapyUrinary Tract Infection PharmacotherapyUrinary Tract InfectionsAcute Upper Respiratory Tract InfectionsEnteric FeverProphylactic Antibiotic TherapyRespiratory Bacterial Infections TreatmentTrimethoprim-sulfamethoxazole ProphylaxisTrimethoprim-sulfamethoxazole TherapyUpper Respiratory InfectionsUrinary Tract Infection Antibiotic Therapy
Trimethoprim and sulfamethoxazole, combined in a synthetic anti-infective preparation, act synergistically to inhibit the growth of certain microorganisms. This combination is effective orally in acute and chronic urinary tract infections. It also has been used successfully to treat other infectious conditions, including bacterial upper respiratory tract infections, ear infections, skin and soft-tissue infections, septicemias, acute and subacute bacterial endocarditis, enteric fever, brucellosis, prostatitis, and gonorrhea. It is well tolerated by most patients.