Drug‐induced long QT syndrome: hERG K⁺channel block and disruption of protein trafficking by fluoxetine and norfluoxetine

Abstract

Our findings show that both fluoxetine and norfluoxetine at similar concentrations selectively reduce IhERG by two mechanisms, (1) direct channel block, and (2) indirectly by disrupting channel protein trafficking. These two effects are not mediated by a single drug binding site. Our findings add complexity to understanding the mechanisms that cause drug-induced long QT syndrome.