Curcumin nanoparticles- a gateway for multifaceted approach to tackle Alzheimer's disease

Abstract

Curcumin is a polyphenolic compound which has been used since ages to treat various ailments. Research in the past few decades has demonstrated its potential therapeutic or preventive effects due to its anti-tumor, anti-inflammatory, anti-oxidative, anti-amyloid, anti-arthritic, anti-ischemic to list a few. In our work, we have successfully synthesized curcumin nanoparticles encapsulated in poly lactic-co-glycolic acid (PLGA) which are water soluble. We would like to harness the anti-amyloid, anti-inflammatory and anti-oxidant activities of curcumin to alleviate the amyloid beta level and other associated changes in Alzheimer disease (AD).