COLD ISCHEMIA IN THE ABSENCE OF ALLOREACTIVITY INDUCES CHRONIC TRANSPLANT NEPHROPATHY THROUGH A PROCESS MEDIATED BY THE PLATELET-ACTIVATING FACTOR1

Abstract

Lewis rats were used as kidney donors and recipients, which were transplanted either immediately or after a cold ischemia period of 5 hr. Contralateral nephrectomy was performed on the seventh day after transplantation. Cyclosporine was administered for 15 days after transplantation. Groups were as follows: Sy, immediate transplantation; SyI, transplantation after 5 hr of cold ischemia; SyIUr, transplantation after 5 hr of cold ischemia plus UR12670 from the transplantation day to the end of the study, at 24 weeks. Serum creatinine, creatinine clearance, and proteinuria were determined every 4 weeks. Urinary