Exploring polyamine regulation by nascent histamine in a human-transfected cell model

Polyamine depletion arrests cell cycle and induces inhibitors p21^Waf1/Cip1, p27^Kip1, and p53 in IEC-6 cells

Ramesh M. Ray, Barbara Zimmerman, Shirley A. McCormack et al. · American Journal of Physiology-Cell Physiology · 1999 · 179 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

Antiproliferative effect of dehydrodidemnin B (DDB), a depsipeptide isolated from Mediterranean tunicates

José Luis Urdiales, Pilar Morata, Ignacio Núñez de Castro et al. · Cancer Letters · 1996 · 139 citations

Life Sciences, Biochemistry, Pharmacology +5

A Simple HPLC Method for the Determination of S-Adenosylmethionine and S-Adenosylhomocysteine in Rat Tissues: The Effect of Vitamin B6 Deficiency on These Concentrations in Rat Liver

Qing‐Bai She, Itsuma Nagao, T. Hayakawa et al. · Biochemical and Biophysical Research Communications · 1994 · 116 citations

Life Sciences, Biochemistry, Micronutrient Deficiency +11

Polyamine depletion in human melanoma cells leads to G1 arrest associated with induction of p21WAF1/CIP1/SDI1, changes in the expression of p21-regulated genes, and a senescence-like phenotype.

Debora L. Kramer, Bey-Dih Chang, Ying Chen et al. · PubMed · 2001 · 89 citations

Life Sciences, Molecular Biology, Oncology +17

Ornithine Decarboxylase Inhibition by α-Difluoromethylornithine Activates Opposing Signaling Pathways via Phosphorylation of Both Akt/Protein Kinase B and p27Kip1 in Neuroblastoma

Dana-Lynn T. Koomoa, Lisette Yco, Tamás Borsics et al. · Cancer Research · 2008 · 68 citations · Full text

Medicine, Cancer Biology, Pharmacology +16