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Simultaneous Study of Haemodynamic, Metabolic and Behavioural Sequelae in a Model of Cerebral Ischaemia in Aged Rats: Effects of Nicergoline
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1984
Year
Cerebral OedemaAgingNicergoline PretreatmentSocial SciencesCerebral Vascular RegulationNeurovascular DiseaseThrombosisAged RatsCerebral IschaemiaBrain InjuryNeurologyNeuropathologyNeuroimmunologyMicrovascular DysfunctionAtherosclerosisIschemic SyndromeMedicineSevere OedemaNeuropharmacologyVascular BiologyCerebral Blood FlowNervous SystemSimultaneous StudyReperfusion InjuryNeurophysiologyNeuroanatomyPhysiologyNeuroscienceStroke
Unilateral cerebral ischaemia was induced in 18-month-old Long-Evans rats by injection of 2,000 labelled microspheres (phi 50 microns) into the carotid blood stream. This results in an ipsilateral decrease in cerebral blood flow, development of severe oedema and modifications of glucose uptake and consumption. Furthermore, this ischaemia led to a deterioration of the avoidance response in conditioned animals. All these disturbances, including the cerebral oedema, diminished with nicergoline pretreatment.