The Significance of the Imidazole Ring in Anticonvulsant Activity of (Arylalkyl)imidazoles

Abstract

Abstract The imidazole ring in nafimidone [1‐(2‐naphthyl)‐2‐(1‐imidazolyl)ethanone] was substituted with various groups to investigate the significance of the imidazole ring in anticonvulsant activity. For this purpose, some 2‐acetylnaphthalene derivatives and their reduction products were synthesized. Several N‐alkylation methods were used to prepare 2‐acetylnaphthalenes. NaBH 4 was used to synthesize their reduction products. Anticonvulsant activities of these compounds were determined by phase I tests of Antiepileptic Drug Development Programme.