Inhibition of Renin Release by Vasopressin and Angiotensin

Abstract

Vasopressin and angiotensin inhibited release of renin induced by lowered renal perfusion pressure. This action could not be related to a measurable haemodynamic change produced by either peptide; in some experiments with vasopressin there was no change in either systemic pressure or renal blood flow. The angiotensin analogues, angiotensin diamide and alanine7 angiotensin II, had no effects on arterial pressure, renal blood flow, or renin release; neither did mixtures of all of the amino acids present in the angiotensin molecule. Oxytocin did not affect renin release when infused in the same doses found to be effective for vasopressin.