Analysis of Results of Kidney Transplantation

Abstract

MANY kidney-transplant recipients have preformed antileukocyte antibodies as a result of previous blood transfusions, kidney transplants or pregnancy.1 When these antibodies are specific for the donor's leukocytes (as indicated by a positive crossmatch test of the recipient's serum and the donor's cells), immediate failure of the transplant is highly probable.2 , 3 Even if these cases are excluded, however, it is our clinical impression that results of kidney transplantation in sensitized recipients are inferior to those in unsensitized recipients. Our analysis of 84 kidney transplants in 79 recipients performed between February 2, 1966, and December 18, 1970, appear to support this impression. . . .