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Effect of various growth conditions on spore formation and bacillomycin L production in <i>Bacillus subtilis</i>
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1986
Year
EngineeringStationary PhaseVarious Growth ConditionsBacteriologyMicrobial PhysiologyCulture MediumDrug ResistanceBacillomycin LBiosynthesisMicrobial EcologyEnvironmental MicrobiologyBacillomycin L ProductionAntimicrobial ResistanceAntimicrobial CompoundSpore BiologyAntimicrobial SusceptibilityAntibioticsMicrobiologySpore FormationMedicine
Bacillomycin L is produced by Bacillus subtilis NCIB 8872 in the stationary phase; it is excreted into the culture medium, without prior accumulation in the bacterial cells. The production of bacillomycin L is largely dependent on the composition of the culture medium. The action of specific inhibitors of sporulation, netropsin and diethyl malonate, on antibiotic synthesis is dependent on the composition of the culture medium. Although they occurred at the same time, there appears to be no direct correlation between sporulation and antibiotic synthesis.