Differential Effects of Central and Peripheral Fat Tissues on the Delayed Rectifier K<sup>+</sup> Outward Currents in Cardiac Myocytes

Abstract

Adipocytokines significantly decreased IK in H9c2 cells, and IK was more prominently decreased by adipocytokines from epicardial fat than from limb fat tissues. The decrease in IK by adipocytokines may partially contribute to the mechanisms of arrhythmogenesis by fat tissues.