Granulin‐epithelin precursor binds directly to ADAMTS‐7 and ADAMTS‐12 and inhibits their degradation of cartilage oligomeric matrix protein

Abstract

Our observations demonstrate a novel protein-protein interaction network between GEP, ADAMTS-7/ADAMTS-12, and COMP. Furthermore, GEP is a novel specific inhibitor of ADAMTS-7/ADAMTS-12-mediated COMP degradation and may play a significant role in preventing the destruction of joint cartilage in arthritis.