Effect of an Aluminum‐ and Magnesium‐Containing Antacid on the Bioavailability of Garenoxacin in Healthy Volunteers

Abstract

Exposure to garenoxacin was significantly decreased when garenoxacin was coadministered with Al-Mg antacid or within 2 hours after the antacid. The magnitude of the changes in garenoxacin exposure suggests that garenoxacin should be administered at least 2 hours before or 4 hours after administration of Al-Mg antacid or other cation-containing products.