High yield synthesis of S-adenosylhomocysteine and related nucleosides by bacterial S-adenosylhomocysteine hydrolase.

Abstract

S-Adenosylhomocysteine (AdoHcy) and related nucleosides have recently attracted great interest as key regulator compounds in many biological transmethylation systems.X) In spite of that the unefulness of these nucleosides in the pharmaceutical and chemotherapeutic fields have been suggested,1} no process for practical production of these compounds has been established yet.