Intraocular Penetration of Semisynthetic Penicillins

Abstract

Four semisynthetic penicillins were administered in varying dosages and their intraocular penetration determined at diffferent intervals. The intraocular penetration of methicillin sodium was irregular with the intravenous and topical route, but negligible when given intramuscularly. When given subconjunctivally there was high inhibitory concentration. Cloxacillin sodium monohydrate penetrated well following intravenous, subconjunctival, and topical administration. Ampicillin anhydrous penetrated well following intravenous, intramuscular, subconjunctival, and topical administration. Carbenicillin disodium penetrated in inhibitory concentrations only when given subconjunctivally in combination with epinephrine. These data are compared with published results.